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Human Umbilical Cord Tissue-Derived Multipotent Mesenchymal Stromal Cells Exhibit Maximum Secretory Activity in the Presence of Umbilical Cord Blood Serum

  • Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Using multiplex analysis, we performed a comparative study of cytokine and growth factor production by human umbilical cord tissue-derived multipotent mesenchymal stromal cells (UC-MSC) cultured under standard conditions and in the presence of human umbilical cord blood serum (UCBS). It was found that the secretion of most studied molecules, including well-known inductors of regeneration HGF, G-CSF, GM-CSF, and VEGF by UCMSC considerably increased in the presence of 5% UCBS. The use of UCBS allows not only obtaining xenogenic-free cellular and cell-free therapeutic products, but also increasing the secretion of most biologically active molecules capable of stimulating repair processes.

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Authors and Affiliations

  1. National Medical Research Center for Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia

    Yu. A. Romanov

  2. V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia

    V. V. Vtorushina, A. Yu. Romanov & G. T. Sukhikh

  3. CryoCenter Cord Blood Bank, Moscow, Russia

    Yu. A. Romanov, T. N. Dugina & N. V. Petrova

Authors
  1. Yu. A. Romanov
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  2. V. V. Vtorushina
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  3. T. N. Dugina
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  4. A. Yu. Romanov
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  5. N. V. Petrova
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  6. G. T. Sukhikh
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Correspondence to Yu. A. Romanov.

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Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 2, pp. 84-88, June, 2020

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Romanov, Y.A., Vtorushina, V.V., Dugina, T.N. et al. Human Umbilical Cord Tissue-Derived Multipotent Mesenchymal Stromal Cells Exhibit Maximum Secretory Activity in the Presence of Umbilical Cord Blood Serum. Bull Exp Biol Med 169, 544–548 (2020). https://doi.org/10.1007/s10517-020-04926-2

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  • DOI: https://doi.org/10.1007/s10517-020-04926-2

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